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Females Are Mosaics: X Inactivation and Sex Differences in Disease
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by Barbara Migeon
Sales Rank: 57778
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List Price: $59.95
$55.80
At Amazon
on 10-25-2008
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Hardcover: 296 pages
Publisher: Oxford University Press, USA; 1 edition March 15, 2007
Language: English
ISBN-10: 0195188128
ISBN-13: 978-0195188127
Product Dimensions:
9.2 x 6.3 x 0.9 inches
Shipping Weight: 1.2 pounds
Product Review
"This book provides a balanced overview of the field to date, allowing newcomers to the field to concentrate on the recent literature necessityThe information in the book is up-to-date and a superb introduction to the entire field for gradutate students and fellows."--Nature
"I thoroughly enjoyed reading this bookThis important and enjoyable book should be read by physicians who care for women of all ages."--New England Journal of Medicine
Product Description
Women can be described as genetic mosaics because they have two distinctly different types of cells throughout their bodies. Unlike males, who have one X chromosome (inherited from their mother), females have two X chromosomes in every cell (one from each parent). The fathers copy works in some cells, while the mothers copy works in others. These two X chromosomes often function differently, especially if one carries a defective gene.
Much has been written about the Y chromosome and its role in inducing maleness. This will be the first book about the X chromosome as a key to female development and the role of X-related factors in the etiology of sex differences in human disease. Barbara Migeon, from the renowned McKusick-Nathan Institute at Johns Hopkins, is a major figure in clinical genetics and is eminently qualified to write this book, and she writes clearly and effectively. She describes both the underlying molecular mechanisms and the remarkable genetic consequences of X inactivation and its role in determining the biological concepts characteristic of women.
Females are Mosaics will be valuable to geneticists, biologists, and all health professionals interested in women's health.
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Females Are Mosaics: X Inactivation and Sex Differences in Disease
Available from Amazon
Price: $55.80
Updated on 10-25-2008
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